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MAF Series

Dietary MAF is a breakthrough in immunotherapy, with global recognition for its clinical effects in serious conditions such as cancer, autism and, more recently, COVID-19. Beyond its therapeutic role in disease recovery, MAF is now drawing attention for its potential in the fields of anti-aging and longevity. Clinical studies suggest it may support telomere elongation and promote the expression of the Klotho gene - both of which are closely associated with cellular health and the aging process. By enhancing immune regulation at the cellular level, Dietary MAF offers promising new avenues not only for treatment, but also for proactive health optimization and healthy lifespan extension.​

Our Research Featured in Science Featured!

We’re proud to share that our latest scientific article has been published in Science Featured!
📰 “How Can You Protect Your Cells From Aging?”

In this article, Dr. Toshio Inui and his research team explore a groundbreaking discovery: a specially modified whey protein (Dietary MAF) that may slow down cellular aging by protecting and lengthening telomeres—the protective caps on our chromosomes.

The study revealed remarkable effects in both young and older mice, suggesting this dietary approach could support long-term cellular health, resilience to age-related decline, and possibly even mental well-being.

Our advertisement feature, Could immune proteins have anti-ageing benefits?, was published on 13 March 2025, as part of Focal Point on Ageing in Japan in the online version of Nature, a weekly international journal publishing the finest peer-reviewed research in science and technology.

Our clinic director, Dr. Toshio Inui, has been featured in Nature!

He discusses the latest in macrophages-normalizing factor (MAF) research and its relationship to telomere protection, longevity, and immune health.

According to research by Saisei Pharma, MAF has the potential to lengthen telomeres and increase the expression of the Klotho gene, slowing the aging process and extending healthy lifespan.

For more information on the relationship between immunity and aging, please see:

https://www.nature.com/articles/d42473-024-00361-3

Rejuvenate and restore your macrophages and dendritic cells with the MAF series

The MAF Series strengthens your immune system without side effects, supporting a youthful and healthy lifestyle. Made from only natural ingredients, the MAF Series is carefully produced in Osaka, Japan.

Unlocking the Secrets of Telomeres, Klotho & Aging​

Unlocking the Secrets of Telomeres, Klotho & Aging​

Ever wondered why we age? The answer lies in telomeres - the protective caps at the ends of our chromosomes- and in key longevity genes like Klotho. Telomeres shorten with each cell division, eventually leading to aging and cellular decline. At the same time, Klotho - often referred to as the "longevity gene"- helps regulate oxidative stress, inflammation, and cellular repair. Together, telomere preservation and enhanced Klotho expression may hold the key to extending both healthspan and lifespan.

Anti-aging and longevity

Anti-aging and longevity

Saisei Mirai's products are developed with the aim of enhancing both beauty and health, with the goal of "looking 20 years younger" and "living a healthy life for over 100 years." Our bodies naturally age as we age, but there are certainly ways to slow down that process.

Macrophages play an important role in the immune system, contributing greatly to anti-aging by eliminating diseased and damaged cells, as well as promoting tissue repair, rejuvenation and regeneration, and helping to fight infection and suppress tumors.

Advancements in Dietary MAF: Unveiling Enhanced Rejuvenation Effects​

Advancements in Dietary MAF: Unveiling Enhanced Rejuvenation Effects​

While Dietary MAF still activates macrophages, its rejuvenation effects are particularly strong. In mouse studies, MAF has shown telomere elongation and increased expression of telomerase (TERT and TERC), making the subjects resemble their younger state. Additionally, the expression of the Klotho gene was also enhanced.

Therefore, we believe that MAF induces rejuvenation through mechanisms beyond macrophage activation—primarily through its effects on telomeres, telomerase (TERT and TERC), and the Klotho gene. We hypothesize that TERT and TERC activation leads to telomere elongation, contributing to longevity.

The role of macrophages

The role of macrophages

What are macrophages?

- Activates the function of cells of the immune system.
- Promotes wound healing and skin repair. - Promotes hair regeneration.
- Phagocytose bacteria and destroy virus-infected cells.
- It takes in and destroys microorganisms.
- Decomposes and removes dead cells.

health

health

Protecting the body from infections
longevity

longevity

Live longer and healthier
Youth

Youth

Slow down the aging process
Energy

Energy

Fighting fatigue
Beautiful Skin

Beautiful Skin

Improves skin condition

Explore articles and more

Keep up to date with the latest news on Saisei Group research, clinical trials, and Dietary MAF products.

Saisei Mirai Clinics Anti-Aging Conference 2025 Osaka

Saisei Mirai Clinics Anti-Aging Conference 2025 Osaka

Theme: Reversing Biological Age – Rejuvenation Join us for an exciting full-day conference dedicated to the most advanced therapies and.
Longevia Summit 2025 — Pioneering the Future of Health and Longevity

Longevia Summit 2025 — Pioneering the Future of Health and Longevity

Longevia Summit 2025 — Pioneering the Future of Health and Longevity Hosted by Lilium Life Institute, the renowned Longevia Summit returns to...
Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice

Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice

Our new article!Oral intake of degalactosylated whey protein increases peripheral blood telomere length in young and aged mice Abstract In order to elucidate...

FAQ

What are macrophages?

Macrophages (from the Greek “big eaters”) are specialized immune cells that develop from monocytes—a type of white blood cell found in our bodies. They play a vital role in the immune system, working across both innate (non-specific) and adaptive (specific) immune responses.

Macrophages are expert "clean-up" cells. They phagocytose—ingest and digest—cellular debris, pathogens, and even cancer cells. Depending on the body’s needs, macrophages can remain in one location or move throughout the body.

In addition to directly attacking harmful invaders, macrophages help activate lymphocytes and other immune cells, coordinating the body’s defense mechanisms and supporting tissue healing, regeneration, and overall immune health.

What is the difference between MAF Capsule Triple and MAF Capsule?


An enhanced version of our original MAF Capsules, MAF Capsules Triple contain three times the active ingredients for even greater immune support.

Product Comparison:

  • MAF Capsules Triple: 300 ng of MAF per capsule
  • MAF Capsules: 100 ng of MAF per capsule
  • M-Lollies: 100 ng of MAF per lozenge
  • M-Powder: 100 ng of MAF per packet

This new formulation is ideal for those seeking a more concentrated daily dose of MAF to support immune function, anti-aging, and overall wellness.

What is the role of macrophages?

Activates immune system cellular activity.

Promotes wound healing and skin repair.

Promotes hair regrowth.

They ingest bacteria and destroy virus-infected cells.

Captures and destroys microorganisms.

Breaks down and removes dead cells.

What is a regenerative future?

Saisei Mirai is a medical institution based in Osaka, Japan, dedicated to patient care and the development of advanced therapeutics - especially immunotherapies like New GcMAF.

We collaborate with clinics, physicians, and research institutions worldwide, and actively participate in clinical trials and ongoing research to advance the field of immunotherapy and improve patient outcomes.

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