Tissue macrophages: Tissue resident macrophages + monocytes
Macrophages exist in nearly all
tissues. Tissue resident macrophages play
critical roles in repair, regeneration and rejuvenation of each tissue.
How innate immunity – especially macrophages – links to longevity?
How innate immunity – especially macrophages – links to longevity?
Macrophages are a type of immune cell.
Macrophages are a type of immune cell. These are a type of white blood cells. They exist in the bodies of all living things and play an important role in keeping us healthy.Macrophages are ameboid cells that play a central role among immune cells. They ingest and break down bacteria and viruses that have invaded the body, as well as harmful substances such as cancer cells.When bacteria and foreign substances are detected in the body, macrophages, which are phagocytic cells, begin eating those pathogens and at the same time, send signals to other immune cells alerting them about the existence of foreign substances. Other immune cells which have received the information also begin to respond to it as well. Pus from a wound and nasal discharge occurring when the body tries to overcome a cold, etc. are the results of immune cell activity.
Activation of macrophages is thought to occur in stages.
Improving immunity strength
Activation stages of macrophages
1. The condition where it is not possible to immediately fight, even when pathogens have invaded the body.
2. The condition where the body can shift into a stance that is ready to fight as soon as pathogens invade the body.
3. A defensive stance where pathogens are confronted and tasks such as “attack”, “decomposition” and “digestion”.
* Condition 2 is called the “priming state.” Maintaining good health and an abundance of macrophages at this activation stage is desirable.
Examples of immunocompromised conditions
Autism
Autism spectrum disorder (ASD) is a serious developmental condition that involves challenges in communication, social interaction, and restricted behaviours.
Cancer
Cancer is a disease of the cells; abnormal cells grow in an uncontrolled way and destroy body tissue.
AIDS
AIDS is a chronic condition caused by HIV infection. The immune system is very damaged and the ability to fight infection is compromised.
Rheumatoid Arthritis
Rheumatoid Arthritis causes joint inflammation, pain, swelling and damage. This is an autoimmune condition.
Crohn’s disease
Crohn's disease is a chronic inflammatory bowel disease. This is considered as an autoimmune condition.
Psoriasis
Psoriasis is a chronic skin condition which skin cells build up and form scales and itchy, dry patches. It’s considered an autoimmune disease. Triggers include infections, stress and cold.
Chronic Fatigue
Chronic Fatigue Syndrome (CFS) is a disease characterised by extreme fatigue for over six months. This fatigue does not improve by rest, and the cause of this condition is unknown.
IBS
Irritable Bowel Syndrome (IBS) is an intestinal disorder, characterised by pain in the stomach, bloating, constipation and diarrhoea.
MS
Multiple sclerosis (MS) is a disease of the central nervous system. The immune system attacks the myelin that protects nerves and affects the brain, spinal cord, and optic nerves.
Introducing the "New Generationof MAF"
What happens when immunity is weakened and what activities are performed by the immunity system have been explained. Within this, macrophages have been described as playing a very important role, and there is a substance that activates macrophages in particular.Based on our collective study achievement, MAF series products can be expected to be effective in activating macrophages.With regards to macrophage-activating substances, there are many ways and various things that exist in this world.One of the features of the MAF series is that it leads the body to prepare for a fight without causing an inflammatory reaction when activating macrophages.We strive to develop products that will help to support the immune system without any side effects.We are thinking about how to help you be healthy every day.